Aspetti Clinici dell'Alimentazione - Studies on the biological properties of green tea catechins (EGCG), and implementation of their use for chemoprevention of cancer, neurodegeneration and cardiovascular diseases
| Indirizzo: Plesso Biotecnologico Integrato, Via Volturno 39 Personale Prof Saverio Bettuzzi - saverio.bettuzzi@unipr.it Prof.ssa Federica Rizzi - federicamariangel.rizzi@unipr.it Prof.ssa Ileana Ramazzina - ileana.ramazzina@unipr.it Dr.ssa Valeria Naponelli - valeria.naponelli@unipr.it Assegnisti - Dottorandi - Borsisti Dr.ssa Aide Negri Dr.ssa Simona Izzo Dr.ssa Chiara lenzi Dr.ssa Marina Marozzi Tecnici di laboratorio Dr.ssa Maria Giovanna Troglio Afferenza: Dipartimento di Medicina e Chirurgia |
COME RAGGIUNGERCI
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Temi di ricerca:
Studio delle proprietà antitumorali di estratti di catechine purificate dal tè verde (Camelia Sinensis). Applicazioni sull’ipertrofia prostatica e il cancro della prostata.
Studio delle proprietà benefiche di estratti di catechine del tè verde in patologie neuro-degenerative e cardiovascolari.
Gli studi sopra descritti vengono eseguiti in modelli cellulari, animali e mediante studi piloti clinici.
Determinazione e quantificazione di catechine, delle molecole correlate e dei loro metaboliti in materiali biologici.
Progettazione e studio delle proprietà di cibi funzionali e nutraceutici basati sulle catechine del tè verde.
Pubblicazioni principali (max 10):
1. Flavonoids as Epigenetic Modulators for Prostate Cancer Prevention. Izzo S, Naponelli V, Bettuzzi S. Nutrients. 2020 Apr 6;12(4):1010. doi: 10.3390/nu12041010. PMID: 32268584 Free PMC article. Review.
2. Molecular Targets of Epigallocatechin-Gallate (EGCG): A Special Focus on Signal Transduction and Cancer. Negri A, Naponelli V, Rizzi F, Bettuzzi S. Nutrients. 2018 Dec 6;10(12):1936. doi: 10.3390/nu10121936. PMID: 30563268 Free PMC article. Review.
3. Long-Term Oral Administration of Theaphenon-E Improves Cardiomyocyte Mechanics and Calcium Dynamics by Affecting Phospholamban Phosphorylation and ATP Production. Bocchi L, Savi M, Naponelli V, Vilella R, Sgarbi G, Baracca A, Solaini G, Bettuzzi S, Rizzi F, Stilli D. Cell Physiol Biochem. 2018;47(3):1230-1243. doi: 10.1159/000490219. Epub 2018 Jun 15. PMID: 29913456 Free article.
4. EGCG antagonizes Bortezomib cytotoxicity in prostate cancer cells by an autophagic mechanism. Modernelli A, Naponelli V, Giovanna Troglio M, Bonacini M, Ramazzina I, Bettuzzi S, Rizzi F. Sci Rep. 2015 Oct 16;5:15270. doi: 10.1038/srep15270. PMID: 26471237 Free PMC article.
5. Polyphenon E(R), a standardized green tea extract, induces endoplasmic reticulum stress, leading to death of immortalized PNT1a cells by anoikis and tumorigenic PC3 by necroptosis. Rizzi F, Naponelli V, Silva A, Modernelli A, Ramazzina I, Bonacini M, Tardito S, Gatti R, Uggeri J, Bettuzzi S. Carcinogenesis. 2014 Apr;35(4):828-39. doi: 10.1093/carcin/bgt481. Epub 2013 Dec 16. PMID: 24343359
6. Chronic administration of green tea extract to TRAMP mice induces the collapse of Golgi apparatus in prostate secretory cells and results in alterations of protein post-translational processing. Davalli P, Rizzi F, Caldara GF, Davoli S, Corti A, Silva A, Astancolle S, Vitale M, Bettuzzi S, Arcari M, Azzali G. Int J Oncol. 2011 Dec;39(6):1521-7. doi: 10.3892/ijo.2011.1136. Epub 2011 Jul 20. PMID: 21935569
7. Green tea catechins suppress the DNA synthesis marker MCM7 in the TRAMP model of prostate cancer. McCarthy S, Caporali A, Enkemann S, Scaltriti M, Eschrich S, Davalli P, Corti A, Lee A, Sung J, Yeatman TJ, Bettuzzi S. Version 2. Mol Oncol. 2007 Sep;1(2):196-204. doi: 10.1016/j.molonc.2007.05.007. PMID: 18521193 Free PMC article.
8. Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study. Bettuzzi S, Brausi M, Rizzi F, Castagnetti G, Peracchia G, Corti A. Cancer Res. 2006 Jan 15;66(2):1234-40. doi: 10.1158/0008-5472.CAN-05-1145. PMID: 16424063 Free article. Clinical Trial.
9. Molecular classification of green tea catechin-sensitive and green tea catechin-resistant prostate cancer in the TRAMP mice model by quantitative real-time PCR gene profiling. Scaltriti M, Belloni L, Caporali A, Davalli P, Remondini D, Rizzi F, Astancolle S, Corti A, Bettuzzi S. Carcinogenesis. 2006 May;27(5):1047-53. doi: 10.1093/carcin/bgi287. Epub 2005 Nov 28. PMID: 16314398
10. The chemopreventive action of catechins in the TRAMP mouse model of prostate carcinogenesis is accompanied by clusterin over-expression. Caporali A, Davalli P, Astancolle S, D'Arca D, Brausi M, Bettuzzi S, Corti A. Carcinogenesis. 2004 Nov;25(11):2217-24. doi: 10.1093/carcin/bgh235. Epub 2004 Sep 9. PMID: 15358631
Key words:
Green Tea, EGCG, Clusterin, CLU, chemoprevention, prostate cancer, TRAMP, cardiomyocytes, gene expression, real-time qPCR, gene signature, Polyphenon E, Theaphenon E, flavonoids, catechins, autophagy, cell death, proliferation, cell cycle, epigenetic modulators, anoikis.